Enzadent Dual Ended Toothbrush for Dogs and Cats Dual-ended bristles (small and large) are specially designed to help remove plaque and food debris from all tooth surfaces. Bristles are soft for gentle application and acceptance by the animal. Directions: Toothbrushing is an important step in maintaining the oral health of your pet. For best results, brush 3-4 times per week using Enzadent Enzymatic Toothpaste. Your veterinarian may give you specific directions. Follow his or her advice closely.